The New Serine Protease Song

(to the tune of “Rudolph the Red-Nosed Reindeer”)

Copyright © 2011 Kevin Ahern
I am very pleased that Mr. David Simmons has made a professional recording of this song (complete song download HERE) and others can be downloaded HERE. You will need to unzip the file to release the MP3. I am providing all songs for free download, but hope you will support this effort by purchasing my Metabolic Melody albums or calendar at the URLs at the bottom of the lyrics to this song.

All serine proteases

Work almost identically

Using amino acid

Triads catalytically

First they bind peptide substrates

Holding onto them so tight

Changing their structure when they

Get them in the S1 site

Then there are electron shifts

At the active site

Serine gives up its proton

As the RE-ac-tion goes on

Next the alkoxide ion

Being so electron rich

Grabs peptide’s carbonyl group

Breaks its bond without a hitch

So one piece is bound to it

The other gets set free

Water has to act next to

Let the final fragment loose

Then it’s back where it started

Waiting for a peptide chain

That it can bind itself to

Go and start all o’er again

Complete list of Metabolic Melodies HERE

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