Serine Protease Song
(To the tune of "Blackbird")
Copyright © 2011 Kevin Ahern
I am very pleased that Mr. David Simmons has made a professional recording of this song (complete song download HERE) and others can be downloaded HERE. You will need to unzip the file to release the MP3. I am providing all songs for free download, but hope you will support this effort by purchasing my Metabolic Melody albums or calendar at the URLs at the bottom of the lyrics to this song.

Substrate floating in the cell’s insides

Enzyme snags it with its binding site

It supplies

Shuffling of electrons in the act to catalyze

Proteases of the serine kind

Break up peptide bonds in rapid time

Fast and slow

Steps in breaking bonds are mechanisms you should know

Asp – his - ser

Bonds beware

Inside the S1 pocket substrate sits

Alkoxides

Break peptides

Nucleophiles give bonds the fits

Peptide one exits easily

But water has to let the other flee

Bound not free

‘Cuz the enzyme’s linked to it in mechanism three

When it’s gone the enzyme’s free to catalyze you see

Complete list of Metabolic Melodies HERE

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