Glucagon is Coming Around
(To the tune of "Santa Claus is Coming to Town")
Copyright © 2004 Kevin Ahern

Tim Karplus' recording HERE

You’ve gotta admire
What molecules do
Their cellular fire
Is ready on cue
Glucagon is coming around

If hormone should bind
Receptor outside
G proteins find
G nucleotides
Glucagon is coming around


They activate cyclases
That make cAMPs
Which bind to Protein Kinase A
And pull the R’s from C’s


The glycogen shrinks
In liver quite fast
The glucose into
Your bloodstream is passed
Thanks to this you have energy

And muscles uptake
The glucose in turn
Obtaining a substrate
All of them burn
Thanks to this you have energy


The pool of phosphatidyl
Inositides in you
Can send two separate signals
When they get split in two


The muscles contract
When calcium’s free
Lowering levels
Of Creatine-P
Now you’re gonna need energy


Those little calcium ions
I hope you’ve learned them well
Are just like Martha Stewart
All locked up in a cell


This story’s complete
I know it’s a load
My hope is your head
Ain’t gonna explode
You will need it in finals week

 

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